Dermal penetration and models


Published by: Lya85
Category: Double penetration

The dermic ability rate of some volatile and non-volatile organic compounds was estimated by quantitative structure–activity state approaches by using explicable unit descriptors. Linear and nonlinear models were mature using multiple linear regressions (MLR) and artificial neural network (ANN) methods. Robustness and reliability of the constructed MLR and ANN models were evaluated by using the leave-one-out cross-validation method, which produces the statistics of for volatile compounds.


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LIPID CHARACTERIZATION OF A NEW EPIDERMAL MODEL FOR SKIN IRRITANCY AND PENETRATION STUDIES.


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These results, on with others showing normal epidermal structure, biochemistry, and function, cater the theoretical basis for use of the Epi Derm model to concentration dermic irritation and peel entry in vitro. Ru O4 stained filamentlike sections observed using gear mechanism negatron research show an cyclic broad-narrow-broad pattern, property of the intercellular lamellae of normal epidermal level corneum. Quantitative thin layer action shows lipid profiles outstandingly close to that of connatural epidermis including the linoleate rich acyl-ceramide (Ceramide 1) which has been powerfully involved in fixing of normal epidermal obstructor function.

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